《Nature》目录要览：2011-01-20出版
时间：2011-01-20 阅读： 我要评论:
http://www.nature.com/nature/journal/v469/n7330/full/469309a.html
Chemical biology: Catalytic detoxification pp310 - 311
Protein engineering of an enzyme that catalytically detoxifies organophosphate compounds in the body opens up fresh opportunities in the search for therapeutic protection against nerve agents used in chemical warfare.
Frank M. Raushel
doi:10.1038/469310a
http://www.nature.com/nature/journal/v469/n7330/full/469310a.html
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INSIGHTS
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EDITORIAL
Frontiers in biology p313
Alex Eccleston, Barbara Marte, Deepa Nath and Clare Thomas
doi:10.1038/469313a
http://www.nature.com/nature/journal/v469/n7330/full/469313a.html
REVIEW
Cells of origin in cancer pp314 - 322
Jane E. Visvader
doi:10.1038/nature09781
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09781.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09781.html
Autophagy in immunity and inflammation pp323 - 335
Beth Levine, Noboru Mizushima and Herbert W. Virgin
doi:10.1038/nature09782
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09782.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09782.html
Pervasive roles of microRNAs in cardiovascular biology pp336 - 342
Eric M. Small and Eric N. Olson
doi:10.1038/nature09783
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09783.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09783.html
The Polycomb complex PRC2 and its mark in life pp343 - 349
Raphaël Margueron and Danny Reinberg
doi:10.1038/nature09784
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09784.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09784.html
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PERSPECTIVES
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Systemic risk in banking ecosystems pp351 - 355
Andrew G. Haldane and Robert M. May
doi:10.1038/nature09659
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09659.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09659.html
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ARTICLES
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Genetic variegation of clonal architecture and propagating cells in leukaemia pp356 - 361
Analysing single cells from human B-cell acute lymphoblastic leukaemias, this study maps the genetic heterogeneity of cells within a given tumour sample, the evolutionary path by which different subclones have emerged, and ongoing dynamic changes associated with relapse. Leukaemia-propagating cells that transplant the disease mirror the genetic variegation of the bulk tumours, providing insights into the heterogeneity of these functional subpopulations at the genetic level. This has implications for therapeutic approaches targeting the tumours and specifically leukaemia-propagating cells.
Chemical biology: Catalytic detoxification pp310 - 311
Protein engineering of an enzyme that catalytically detoxifies organophosphate compounds in the body opens up fresh opportunities in the search for therapeutic protection against nerve agents used in chemical warfare.
Frank M. Raushel
doi:10.1038/469310a
http://www.nature.com/nature/journal/v469/n7330/full/469310a.html
----------------------
INSIGHTS
----------------------
EDITORIAL
Frontiers in biology p313
Alex Eccleston, Barbara Marte, Deepa Nath and Clare Thomas
doi:10.1038/469313a
http://www.nature.com/nature/journal/v469/n7330/full/469313a.html
REVIEW
Cells of origin in cancer pp314 - 322
Jane E. Visvader
doi:10.1038/nature09781
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09781.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09781.html
Autophagy in immunity and inflammation pp323 - 335
Beth Levine, Noboru Mizushima and Herbert W. Virgin
doi:10.1038/nature09782
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09782.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09782.html
Pervasive roles of microRNAs in cardiovascular biology pp336 - 342
Eric M. Small and Eric N. Olson
doi:10.1038/nature09783
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09783.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09783.html
The Polycomb complex PRC2 and its mark in life pp343 - 349
Raphaël Margueron and Danny Reinberg
doi:10.1038/nature09784
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09784.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09784.html
----------------------
PERSPECTIVES
----------------------
Systemic risk in banking ecosystems pp351 - 355
Andrew G. Haldane and Robert M. May
doi:10.1038/nature09659
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09659.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09659.html
----------------------
ARTICLES
----------------------
Genetic variegation of clonal architecture and propagating cells in leukaemia pp356 - 361
Analysing single cells from human B-cell acute lymphoblastic leukaemias, this study maps the genetic heterogeneity of cells within a given tumour sample, the evolutionary path by which different subclones have emerged, and ongoing dynamic changes associated with relapse. Leukaemia-propagating cells that transplant the disease mirror the genetic variegation of the bulk tumours, providing insights into the heterogeneity of these functional subpopulations at the genetic level. This has implications for therapeutic approaches targeting the tumours and specifically leukaemia-propagating cells.
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