英国《Nature》目录要览：2010-04-01出版
时间：2010-04-02 阅读： 我要评论:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08819.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08819.html
Impaired hippocampal-prefrontal synchrony in a genetic mouse model of
schizophrenia pp763-767
A deletion on human chromosome 22 (22q11.2) is one of the largest genetic
risk factors for schizophrenia. Mice with a corresponding deletion have
problems with working memory, one feature of schizophrenia. It is now found
that these mice also show disruptions in synchronous firing between neurons
of the prefrontal cortex and of the hippocampus, an electrophysiological
phenomenon that has been linked to learning and memory and which is also
thought to be disrupted in schizophrenia patients.
Torfi Sigurdsson et al.
doi:10.1038/nature08855
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08855.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08855.html
Understanding mechanisms underlying human gene expression variation with RNA
sequencing pp768-772
There is much interest in understanding the genetic mechanisms that underlie
individual variations in gene expression. Here, RNA sequencing has been used
to study gene expression in lymphoblastoid cell lines derived from Nigerian
individuals for whom extensive genotype information is known. Numerous
genetic
determinants of variation in gene expression were identified, including
variation in transcription, splicing and allele-specific expression.
Joseph K. Pickrell et al.
doi:10.1038/nature08872
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08872.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08872.html
Transcriptome genetics using second generation sequencing in a Caucasian
population pp773-777
Here, sequencing has been used to characterize the mRNA fraction of the
transcriptome in Caucasian individuals, to provide a fine-scale view of
transcriptomes and to identify genetic variants that affect alternative
splicing. Measuring allele-specific expression identified rare expression
quantitative trait loci (eQTLs) and allelic differences in transcript
structure, revealing new properties of genetic effects on the transcriptome.
Stephen B. Montgomery et al.
doi:10.1038/nature08903
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08903.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08903.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08819.html
Impaired hippocampal-prefrontal synchrony in a genetic mouse model of
schizophrenia pp763-767
A deletion on human chromosome 22 (22q11.2) is one of the largest genetic
risk factors for schizophrenia. Mice with a corresponding deletion have
problems with working memory, one feature of schizophrenia. It is now found
that these mice also show disruptions in synchronous firing between neurons
of the prefrontal cortex and of the hippocampus, an electrophysiological
phenomenon that has been linked to learning and memory and which is also
thought to be disrupted in schizophrenia patients.
Torfi Sigurdsson et al.
doi:10.1038/nature08855
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08855.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08855.html
Understanding mechanisms underlying human gene expression variation with RNA
sequencing pp768-772
There is much interest in understanding the genetic mechanisms that underlie
individual variations in gene expression. Here, RNA sequencing has been used
to study gene expression in lymphoblastoid cell lines derived from Nigerian
individuals for whom extensive genotype information is known. Numerous
genetic
determinants of variation in gene expression were identified, including
variation in transcription, splicing and allele-specific expression.
Joseph K. Pickrell et al.
doi:10.1038/nature08872
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08872.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08872.html
Transcriptome genetics using second generation sequencing in a Caucasian
population pp773-777
Here, sequencing has been used to characterize the mRNA fraction of the
transcriptome in Caucasian individuals, to provide a fine-scale view of
transcriptomes and to identify genetic variants that affect alternative
splicing. Measuring allele-specific expression identified rare expression
quantitative trait loci (eQTLs) and allelic differences in transcript
structure, revealing new properties of genetic effects on the transcriptome.
Stephen B. Montgomery et al.
doi:10.1038/nature08903
Abstract:
http://www.nature.com/nature/journal/v464/n7289/abs/nature08903.html
Article:
http://www.nature.com/nature/journal/v464/n7289/full/nature08903.html
| 《Nature》目录要览 — 2011-04-28出版 |
| 《Nature》目录要览：2011-01-20出版 |
| 《Nature》目录要览：2010-12-23出版 |
| 《Nature》目录要览：2010-12-16出版 |
| 《Nature》目录要览：2010-12-09出版 |
| 《Nature》目录要览：2010-12-02出版 |
特别声明：本文转载仅仅是出于传播信息的需要，版权归原作者所有，并不意味着代表本网站观点或证实其内容的真实性； 如其他媒体、网站或个人从本网站转载使用，须保留本网站注明的“来源”，并自负版权等法律责任； 作者如果不希望被转载或者联系转载稿费等事宜，请与我们接洽：service#environmentor.cn（请将#改为@）。
来源：Nature 作者：Environmentor （环境人 Environmentor.Cn）
