Kristina Anderson et al.
doi:10.1038/nature09650
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09650.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09650.html

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells pp362 - 367
Analysing human B-cell acute lymphoblastic leukaemias, this study maps  the genetic heterogeneity of cells within a given tumour sample and  the evolutionary path by which different subclones have emerged.  Leukaemia-initiating cells that transplant the disease mirror the  genetic variegation of the bulk tumours, providing insights into the  heterogeneity of these functional subpopulations at the genetic level.  This has implications for therapeutic approaches targeting the tumours  and specifically leukaemia-initiating cells.
Faiyaz Notta et al.
doi:10.1038/nature09733
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09733.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09733.html

Nascent transcript sequencing visualizes transcription at nucleotide  resolution pp368 - 373
A novel technique called native elongating transcript sequencing (NET- seq) is described, which can quantify transcription with single  nucleotide resolution. It is based on sequencing nascent transcripts  associated with RNA polymerase II that are captured directly from live  cells, and is used to gain insights into polymerase pausing and  backtracking and the directionality of transcription.
L. Stirling Churchman and Jonathan S. Weissman
doi:10.1038/nature09652
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09652.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09652.html

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LETTERS
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Supermassive black holes do not correlate with galaxy disks or  pseudobulges pp374 - 376
The masses of supermassive black holes are known to correlate with the  properties of the bulge components of their host galaxies. In  contrast, they appear not to correlate with galaxy disks. Disk-grown  pseudobulges are intermediate in properties between bulges and disks.  This paper reports pseudobulge classifications for a sample of nearby  galaxies, and combines them with recent measurements of velocity  dispersions in the biggest bulgeless galaxies to confirm that black  holes do not correlate with disks, and that they correlate little or  not at all with pseudobulges.
John Kormendy, R. Bender and M. E. Cornell
doi:10.1038/nature09694
Abstract: http://www.nature.com/nature/journal/v469/n7330/abs/nature09694.html
Article: http://www.nature.com/nature/journal/v469/n7330/full/nature09694.html

Supermassive black holes do not correlate with dark matter haloes of  galaxies pp377 - 380
Supermassive black holes have been detected in all galaxies that  contain bulge components. Bigger black holes are found in bigger  bulges, implying that black-hole growth and bulge formation regulate  each other. Reports of a similar correlation between black holes and  the dark matter haloes suggest that unknown, exotic physics controls  black-hole growth. Here it is shown that there is almost no  correlation between dark matter and parameters that measure black  holes unless the galaxy also contains a bulge. It is concluded that  black holes do not correlate directly with dark matter, and that black  holes coevolve only with bulges.

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